ORAL CANCER INDUCED TRPV1 SENSITIZATION IS MEDIATED BY PAR2 SIGNALING IN PRIMARY AFFERENT NEURONS INNERVATING THE CANCER MICROENVIRONMENT

Oral cancer induced TRPV1 sensitization is mediated by PAR2 signaling in primary afferent neurons innervating the cancer microenvironment

Abstract Oral cancer patients report sensitivity to spicy foods and liquids.The mechanism responsible for chemosensitivity induced by oral cancer is not known.We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model using two-bottle choice drinking and conditioned place aversion assays.An anatomic basis of chemosensit

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Impacts of fertilization on grassland productivity and water quality across the European Alps under current and warming climate: insights from a mechanistic model

Alpine grasslands sustain local economy by providing fodder for livestock.Intensive fertilization is common to enhance their yields, thus creating negative externalities on water quality that are difficult to evaluate without reliable estimates of nutrient fluxes.We apply a mechanistic ecosystem model, seamlessly integrating land-surface energy bal

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